Expression of Bcl-2 and calretinin in dysplasia enteric ganglion cells of hirschsprung patients
- VernacularTitle:Bcl-2、钙视网膜蛋白在发育异常肠壁神经节细胞中的表达
- Author:
Jin ZHU
;
Xianqing JIN
- Publication Type:Journal Article
- Keywords:
hirschsprung disease;
Bcl-2;
calretinin;
immunohistochemistry
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of Bcl-2 and calretinin(CR)in enteric ganglion cells in different developmental conditions and its significance.Methods The immunohistochemical staining was carried out to detect the expression of Bcl-2 and CR in enteric ganglion cells at different intestinal segments from tissue samples of 40 hirschsprung disease(HD) cases(age,26 d to 12 years old),10 Hirschsprung's allied disease(HAD) cases and 10 normal controls.Results In immature ganglion cells,there was a strong expression of Bcl-2,and no positive to or poor expression of CR.In mature ganglion cells,there was a strong expression of CR but no positive Bcl-2 staining.Conclusion The specific expression of Bcl-2 and CR may play an essential role in judging if the ganglion cells are mature.Bcl-2 might be of importance in the maintenance and restore of the fuction of enteric immature ganglion cells.
