Effect of Astragalus Root Injection on hippocampal neuronal apoptosis induced by axaliplatin
- VernacularTitle:黄芪注射液对奥沙利铂致海马神经细胞凋亡的抑制作用
- Author:
Oujing LI
;
Huijuan CUI
;
Meiyan HUANG
;
Huangying TAN
;
Yuan LI
;
Zhi QI
- Publication Type:Journal Article
- Keywords:
Astragalus root;
Astragalus Root Injection;
Oxaliplatin(L-OHP);
Neurotoxicity;
Nerve growth factor (NGF);
Hippocampus neuron;
Apoptosis
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of Astragalus Root Injection(a traditional Chinese herb medicine) on oxaliplatin-induced apoptosis of hippocampal neurons. Motheds: The primary culture of hippocampus neurons from SD rats (aged within 24h) were treated with different concentrations of oxaliplatin( L-OHP) (0, 3, 5 and 10 ?g/mL) and Astragalus Root Injection (0.05, 0.2 and 0.5 g/mL). The apoptosis of the neurons and the nerve growth factor(NGF)level were analyzed. Results: Astragalus Root Injection dose-dependently decreased neuronal cell apoptosis induced by oxaliplatin (P
