Effects of chronic anger stress on rats' aging process and neuroendocrine-immune mechanism
- VernacularTitle:慢性愤怒应激对大鼠衰老进程及其神经内分泌免疫机制的影响
- Author:
Xianghong ZHAN
;
Wei LI
;
Junmei ZHAO
;
Weiwei XU
;
Xue YANG
;
Shengli LIU
- Publication Type:Journal Article
- Keywords:
Anger;
Stress;
Aging;
Monoamine neurotransmitters;
Corticosterone
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of chronic anger stress on rats' aging process and the mechanism of the neuroendocrine-immune network. Methods:After the aging and brain aging rats induced by D-galactose(D-gal) were stimulated by anger, observation of the effects of chronic anger stress on the rats' spatial learning and memory was made, the contents of norepinephrine(NE), 5-hydroxytryptamine(5-HT)in brain tissue and serum, the levels of adrenocorticotropic hormone (CORT) in serum were assayed, the spleen index was measured. Results:Compared with the D-gal group, in the D-gal group stimulated by anger, the rats' ability of spatial learning and memory declined, the contents of NE in brain tissue and serum increased, the contents of 5-HT declined, the levels of CORT in serum increased, and the spleen index declined. Conclusion: The rats' aging and brain aging were aggravated and the aging process were accelerated by chronic anger stress. The possible mechanism were the sustained excitability of the HPA axis and SAS, disturbances of neuroendocrine system and immunological function repression.
