Influence of 1,25-(OH)_2D_3 and salvia miltiorrhiza on T cell subsets and immune status in rats after allogeneic bone marrow transplantation
- VernacularTitle:1,25-(OH)_2D_3及复方丹参对大鼠异基因骨髓移植后T细胞亚群和细胞因子的影响
- Author:
Mei YAN
;
Bingzhao WEN
;
Yan CAO
;
Jun HU
;
Ming JIANG
- Publication Type:Journal Article
- Keywords:
allogeneic bone marrow transplantation;
T cell subsets;
cytokine;
1,25-(OH)2D3;
salvia miltiorrhiza
- From:Journal of Third Military Medical University
2003;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of 1,25-(OH)2D3 and salvia miltiorrhiza on T cell subsets and cytokines in rats after allogeneic bone marrow transplantation.Methods Female Wistar rats were used as recipients and male SD rats were used as donors.All Wistar rats were divided into aGVHD group and intervention groups at random,and the intervention groups were further divided into 1,25-(OH)2D3 group,salvia miltiorrhiza group and combination group.The changes of T cell subsets (CD4+ and CD8+) and cytokine (IL-2,IFN-?,IL-4 and IL-10) in every group were detected and measured.Results When the presentation of aGVHD was relatively conspicuous,CD4+ and CD8+ were increased,and the increase of CD4+ was predominant.Compared with the difference prior to transplantation,the difference was statistically significant (P
