Acute Toxicity Analgesic and Antiinflammatory Effects of Snake Compound
- VernacularTitle:复方蛇制剂急性毒性及镇痛抗炎药效研究
- Author:
Yanxia LIU
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
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Abstract:
Snake compound (SC)consisted of the alcoholic extract of Zaocys dhumnades,Agkistrodon halys(Pallas)compounded with Chinese herbs: Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao, Angelica sinensis (Oliv) Diels, Rehmannia glutinosa Libosch, Paris pollyphylla Sm. var. yunancnsis, Epimedium brevicornum Maxim and Salvia miltiorrhiza Bge.. Acute toxicity test showed that the maximum tolerant oral dose for mice was 120mg/kg, 1091 times higher than the dose used in clinic for patients. Analgesic and anti-inflammatory studies showed that the times of writhe induced by abdominal administration of acetic acid were decreased significantly and the pain thre shold of electrical stimuli was increased markedly by SC in mice. The analgesic effects were dose-dependent. Inflammatory swelling in digiti pedis of rats induced by carrageenin and swelling of ear in mice were alleviated dramatically by SC.SC showed good effects in the treatment of winddampness syndrome and anthralgia syndrome in clinic.
