Patho-physiological function of activiated renal renin-angiotensin system in hypertension and kidney disease
- VernacularTitle:高血压与肾脏疾病中肾脏局部肾素-血管紧张素系统的激活及病理生理作用
- Author:
Jinxiu CAO
;
Liping ZHANG
;
Chunlin GAO
;
Junya JIA
- Publication Type:Journal Article
- Keywords:
renin-angiotensin system;
hypertension;
angiotensin converting enzyme inhibitor;
kidney disease
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
There is an independent-regulated renin-angiotensin system(RAS)in kidney.Most of patients with hypertension or kidney diseases present increased renal RAS activity,which maintains body water and sodium balance,but contributes to the occurrence of hypertension and renal damage progression.The article reviewes some recent basic and clinical researches,focusing on the renal RAS activation mechanisms,consequences and clinical significance of the intervention of RAS blockers,which may help us recognize local RAS function of kidney,explore the treatment strategies to control hypertension and slow chronic kidney disease progression.
