Urotensin Ⅱ aggravated ?-glycerophosphate-stimulated calcification in cultured rat vascular smooth muscle cells
- VernacularTitle:尾加压素Ⅱ加重?-甘油磷酸诱导的大鼠血管平滑肌细胞钙化
- Author:
Baohong ZHANG
;
Xiaobo CHEN
;
Erzhen LI
;
Tianyou WANG
;
Chaoshu TANG
;
Junbao DU
- Publication Type:Journal Article
- Keywords:
calcification;
urotensin Ⅱ;
vascular smooth muscle cells;
cell phenotype;
rat
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of urotensin Ⅱ on vascular calcification.Methods Calcified VSMCs of rat in vitro were induced by ?-glycerophosphate.Cellular calcium content,ALP activities,45Ca accumulation and osteocalcin content were measured.Results Compared with those of control group,calcium content,ALP activities,45Ca uptake and osteocalcin in calcified VSMCs increased greatly(P
