Expression of E6 oncoprotein of HPV16,cyclin D_1,and human telomerase transcriptase in nasopharyngeal carcinoma tissues and its significance
- VernacularTitle:人乳头瘤病毒16E6蛋白、细胞周期素D_1及端粒酶逆转录酶在鼻咽癌组织中的表达及意义
- Author:
Lizhu JIANG
;
Caifeng L
;
Hongyi LU
;
Hongyan CHEN
- Publication Type:Journal Article
- Keywords:
nasopharyngeal neoplasms;
E6 oncoprotein of HPV16;
cyclin D1;
telomerase transcriptase;
immunohistochemistry
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the role of HPV16E6,cyclin D1,and human telomerase transcriptase(hTERT) in the development and progression of nasopharyngeal carcinoma(NPC) and to discuss the clinical significance.Methods: Immunohistochemistry was used to detect the expression of HPV16E6,cyclin D1,and hTERT in paraffin-embedded nasopharyngeal carcinoma tissues and nasopharyngeal chronic inflammation tissues.The relationship between their expression with the clinicopathological features of NPC was analyzed;the influence of their expression on prognoses of patients was also analyzed.Results: The positive rates of HPV16E6,cyclin D1,and hTERT in NPC tissues were 62.5%(35/56),50.0%(28/56),and 67.9%(38/56),respectively,which were significantly higher than those in the inflammation tissues(P0.05).HPV16E6 expression was positively correlated with cyclin D1(r=0.480,P