Effects of Bu Shen Huo Xue on Ovarian Granulose Cell Apoptosis of DOS Rats Induced by GTW
- VernacularTitle:补肾活血中药对雷公藤致卵巢储备下降大鼠颗粒细胞凋亡的影响
- Author:
Xiaofeng XU
;
Yong TAN
;
Xuanyi CHEN
- Publication Type:Journal Article
- Keywords:
BuShenHuoXue;
Ovary reserve;
Granular cell;
Apoptosis
- From:
Journal of Medical Research
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effects of BuShenHuoXue on ovarian granulose cell apoptosis of DOS rats induced by GTW. Methods Sixty 12 -week -old female SD rats were randomly divided into 6 groups:control, model GTW,low dose of BuShenHuoXue Formula, middle dose of BuShenHuoXue Formula, high dose of BuShenHuoXue Formula, and LiuWeiDiHuang soup group. The ovary index, pathomorphological configuration,the level of E_2 and FSH in blood serum, and the expression of granular cell apoptosis protein Bcl - 2, Bax and Caspase - 3 was obserred after giving rats the different drugs separately. Results The expression of Bcl - 2, Caspase - 3 : as compared with control,the model, BuShenHuoXue low dose had a significant difference ( P
