Phosphorylized ERK1/2 is upregulated in diabetic rats after global cerebral ischemia-reperfusion injury
- VernacularTitle:糖尿病大鼠脑缺血再灌注海马CA4区神经元中磷酸化ERK1/2的表达上调
- Author:
Yi MA
;
Li JING
;
Fengying GUO
;
Jianzhong ZHANG
- Publication Type:Journal Article
- Keywords:
diabetes;
cerebral ischemia-reperfusion injury;
extracellular signal-regulated kinase1/2;
hippocampus;
apoptosis
- From:Journal of Third Military Medical University
2003;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of extracellular signal-regulated kinase 1/2 (ERK1/2) in the hippocampus CA4 region of diabetic rats after global cerebral ischemia-reperfusion injury. Methods Diabetic rat was established by intraperitoneal injection of streptozocin (STZ) and then global cerebral ischemia model was induced by bilateral clamping of the carotid arterial plus hypotension by withdrawing blood. Apoptosis of neuron and expression of the phosphorylation of ERK1/2 (P-ERK1/2)were observed in the hippocampus CA4 region of diabetes operation groups (DCI) and normoglycemia operation groups (NCI) by TUNEL,immunohistochemistry at 15 min after ischemia and at 1 h after reperfusion. Results Compare with the NCI,neuronal apoptosis of DCI was significantly higher at each time point of cerebral ischemia and reperfusion in the hippocampus CA4 (P
