Effect of Lingqi Capsule on expression VEGF,MMP-2 and MMP-9 in A549 cell
- VernacularTitle:灵芪胶囊对肺癌A549细胞的VEGF、MMP-2、MMP-9表达的影响
- Author:
Hongting WANG
;
Yunming SU
- Publication Type:Journal Article
- Keywords:
LingQi Capsule;
VEGF;
MMP-2;
MMP-9
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In occurrence and development process oflung cancer, the only known angiogenesis is one element ofthe growth, proliferation and aversion oftumor cells.VEGF, MMP-2 and MMP-9 play important role in the development and aversion ofA549 cell.This experiment is to reveal the effect ofLingqi Capsule on expression VEGF, MMP-2 and MMP-9 in A549 cell and mechanism ofanti-tumor.Methods:Medicated serum was prepared with serum-pharmacology methods, the the effect ofmedicated serum on VEGFmRNA and protein expressions ofMMP-2 and MMP-9 was detected by RT-PCR technology and immunohistochemistry respectively.Results:It suggested that the VEGF mRNAcorrect value ofthe administration group was respectively(0.804?0.020),(0.836?0.022)and(0.914?0.009),the blank control group was(0.905? 0.033)and positive control group was(0.766?0.014).Difference between the administration group and the blank control group was significant(P
