Effect of Chinese herbal medicine of removing toxic and blood stasis and nourishing yin on lymphocyte apoptosis in spleen of lupus mouse and expression of Cyt-C and Bcl-2
- VernacularTitle:解毒祛瘀滋阴方对狼疮鼠脾淋巴细胞凋亡及相关基因的调控
- Author:
Jian CHEN
;
Yongsheng FAN
;
Chengping WEN
;
Dan XU
;
Bo JIN
;
Weimin ZHOU
;
Fusheng JIANG
- Publication Type:Journal Article
- Keywords:
Chinese herbal medicine ofremoving toxic and blood stasis and nourishing yin;
MRL/lpr mouse;
Apoptosis;
Cyt-C mRNA;
Bcl-2 mRNA
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the effect ofChinese herbal medicine ofremoving toxic and blood stasis and nourishing yin on lymphocyte apoptosis in spleen ofMRL/lpr mouse and expression ofCyt-C and Bcl-2.Methods:50 2-month-old male MRL/lpr mouse and 10 2-month-old male C57BL/6 mouse were randomly divided into six groups:high, middle and low dosage groups, pre-treatment group, model group and control group.After 30days treatment, the lymphocyte apoptosis in spleen oflupus mouse and expression ofCyt-C mRNA and Bcl-2 mRNA were detected.Results:The percentages oflymphocyte apoptosis in model group were(57.18?1.72)% lower than that in normal group(78.99?3.76)%(P
