Study on pharmacokinetics of brucine from normal and ultra-micro powder of semen strychni in rats
- VernacularTitle:不同粒径马钱子粉体中士的宁在大鼠体内的药代动力学研究
- Author:
Long ZOU
;
Hui GUI
;
Shichao HUANG
;
Zhengping TANG
;
Guangxian CAI
- Publication Type:Journal Article
- Keywords:
Semen strychni;
Ultra-micro powder;
Normal powder;
Brucine;
Pharmacokinetics
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the pharmacokinetic process ofbrucine from normal and ultra-micro powder ofsemen strychni in rat serum.Methods:HPLC techniques were used.All pharmacokinetics parameters were calculated with a 3P87 program.Results:The pharmacokinetics results indicated that the normal powder and the ultra-micro powder ofsemen strychni belonged to two compartment open model.The absorb ofbrucine was just several ten minutes, and there was no obvious difference ofTmax between normal powder and ultra-micro powder.This showed that:Brucine was some material that was easily absorbed.But we can find that Cmax increased from(51.13?0.48)?g/L to(69.26?1.40)?g/L after ultra-micro powder preparation which was quite obvious.K,Ka,B and ? had a obvious increase(P
