Effects of combination of puerarin and glucose tolerance factor(GTF) at molecular level on gene expressions of leptin receptor
- VernacularTitle:葛根素与葡萄糖耐量因子分子水平配伍对瘦素受体基因表达的影响
- Author:
Jin LI
;
Yaming LIU
;
Daohui DU
;
Zhiguang ZHAI
- Publication Type:Journal Article
- Keywords:
GTF;
Pueraria;
Obesity;
Leptin receptor
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In this article, pueraria extract combined with glucose tolerance factor(GTF) , extracted from yeast, at molecular level.We studied the mechanism ofnew compatibility ofTCM on target organ in treating obesity and analyzed the TCM's theory ofcompatibility with mutual reinforcement and searched a new breakthrough on grouping prescriptions ofTCM.Methods:We study the pharmacodynamics ofpueraria extract(puerarin)combining with GTF by being compared with puerarin, GTF and control medicine respectively by determining the gene expression ofleptin receptor(OB-R).Results:At the fourth week, compared with the obesity model group, the expression ofOB-R in the puerarin combining with GTF group increased significantly(P
