Morphological and ultrastructural changes of the neuro-endocrine-immune network in the tumor transplantation animal model of abnormal Savda syndrome
- VernacularTitle:异常黑胆质肿瘤动物模型下丘脑-垂体-肾上腺轴形态学的改变
- Author:
Li ZHANG
;
Upur HALMURAT
;
Ali MAYINUER
;
Hanhua HU
;
Aomaiti NUERMAIMAITI
;
Abulimiti ADILI
- Publication Type:Journal Article
- Keywords:
Abnormal Savda syndrome;
Abnormal Savda syndrome tumor;
Animal model;
NEI
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Abnormal Savda syndrome transplantation tumor model was established on the basis ofabnormal Savda syndrome model in order to study the relevance between the abnormal Savda syndrome tumor and the disorder ofthe neuroendocrine-immune network by analyzing morphological and ultrastructural changes ofthe hypothalamus-pituitary-adrenal axis(HPAA).Methods:120 ICR mice were divided randomly into four groups(control, tumor model, abnormal Savda syndrome model, and abnormal Savda syndrome tumor transplantation model).The structural changes in hypothalamus, pituitary and adrenal glands were analyzed by bright-field and electron microscopy.Results:First, in abnormal Savda syndrome, the rate oftumor transplantation was increased significantly than in the normal state(93.3% and 56.7%, respectively, P
