Prognostic Factors in Patients with Advanced Pancreatic Cancer Treated with Gemcitabine Chemotherapy: Clinical Characteristics of Long-term Survivors.
10.4166/kjg.2014.64.6.356
- Author:
Sung Gyu AN
1
;
Dong Uk KIM
;
Geun Am SONG
;
Ae Lee JANG
Author Information
1. Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. amlm3@hanmail.net
- Publication Type:Original Article ; English Abstract
- Keywords:
Pancreatic cancer;
Gemcitabine;
Long-term survival;
Prognostic factor
- MeSH:
Age Factors;
Aged;
Antimetabolites, Antineoplastic/*therapeutic use;
Blood Urea Nitrogen;
CA-19-9 Antigen/blood;
Deoxycytidine/*analogs & derivatives/therapeutic use;
Female;
Humans;
Logistic Models;
Male;
Middle Aged;
Neoplasm Staging;
Odds Ratio;
Pancreatic Neoplasms/*drug therapy/mortality/pathology;
Prognosis;
Proportional Hazards Models;
Retrospective Studies;
Sex Factors;
Survival Rate
- From:The Korean Journal of Gastroenterology
2014;64(6):356-363
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Gemcitabine-based chemotherapy has been used as a standard treatment in patients with unresectable pancreatic cancer. However, the clinical outcomes of this regimen are still unsatisfactory in prolonging survival. We retrospectively analyzed clinical characteristics of patients with advanced pancreatic cancers who received gemcitabine-based chemotherapy and showed long-term survival. METHODS: We enrolled 49 patients who underwent treatment with more than three cycles of gemcitabine-based chemotherapy. Long-term survivor was defined as patient who has survived more than 12 months after diagnosis. The clinical characteristics were analyzed to compare the differences between long-term and short-term survivors. Univariate or multivariate analyses were performed to identify prognostic factors associated with chemo-responses. RESULTS: Twenty patients (41%) survived more than 12 months. Long-term survivors had smaller tumor size (OR 2.190, p=0.049, 95% CI 1.005-4.773) and higher serum BUN level (OR 0.833, p=0.039, 95% CI 0.701-0.990) compared to short-term survivors. Overall median and progression-free survivals were 11 and 4 months, respectively. Presence of distant metastasis (hazard ratio 1.441, p=0.035, 95% CI 1.002-2.908) was a significant independent predictor of progression-free survival. Tumor size (hazard ratio 1.534, p=0.004, 95% CI 1.150-2.045) was associated with overall survival. CONCLUSIONS: Gemcitabine chemotherapy may be more effective and allow longer survivals in patients with clinical characters of smaller tumor size and normal serum BUN level at diagnosis. We suggest a well-designed large controlled study to evaluate the prognostic factors such as clinical characteristics and molecular biological features in patients with advanced pancreatic cancers who receive gemcitabine-based chemotherapy.
