A Case of Metachronous Development of Esophageal Squamous Cell Carcinoma in the Patient with Esophageal Carcinosarcoma.
10.4166/kjg.2014.64.6.364
- Author:
Ra Ri CHA
1
;
Woon Tae JUNG
;
Hye Won OH
;
Hee Jin KIM
;
Chang Yoon HA
;
Hong Jun KIM
;
Tae Hyo KIM
;
Gyung Hyuck KO
Author Information
1. Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. wtjung@gnu.ac.kr
- Publication Type:Case Reports
- Keywords:
Esophageal squamous cell carcinoma;
Carcinosarcoma;
Spindle cell carcinoma
- MeSH:
Antineoplastic Agents/therapeutic use;
Carcinoma, Squamous Cell/*diagnosis/drug therapy/pathology;
Carcinosarcoma/*diagnosis/drug therapy/pathology;
Cisplatin/therapeutic use;
Drug Therapy, Combination;
Endoscopy, Digestive System;
Esophageal Neoplasms/*diagnosis/drug therapy/pathology;
Fluorouracil/therapeutic use;
Humans;
Male;
Middle Aged;
Positron-Emission Tomography;
S100 Proteins/metabolism;
Tomography, X-Ray Computed;
Tumor Suppressor Protein p53/metabolism
- From:The Korean Journal of Gastroenterology
2014;64(6):364-369
- CountryRepublic of Korea
- Language:English
-
Abstract:
Esophageal carcinosarcoma is a rare malignant esophageal neoplasm consisting of both carcinomatous and sarcomatous elements, with an incidence of 0.5%. There have been only a few case reports of carcinosarcoma and squamous cell carcinoma coexisting in the esophagus. However, all of these are cases of synchronous or metachronous development of carcinosarcoma after chemoradiotherapy in patients of esophageal squamous cell carcinoma. A 53-year-old man underwent esophagogastroduodenoscopy because of chest pain for several months. Endoscopic examination revealed a huge pedunculated esophageal polypoid mass. Endoscopic submucosal dissection (ESD) was performed and histopathologic examination confirmed spindle cell carcinoma (carcinosarcoma). He refused additional esophagectomy. After 21 months, third follow-up endoscopy showed poorly-demarcated flat, faint discolored lesions at different location from the previous ESD site and endoscopic biopsies confirmed squamous cell carcinoma. To the best of our knowledge, this is the first case of metachronous development of esophageal squamous cell carcinoma in a patient with esophageal carcinosarcoma.
