Establishment of sinoatrial node damage model in canine induced by formaldehyde wet dressing of sinoatrial node aera
- VernacularTitle:窦房结区甲醛湿敷法建立犬窦房结损伤模型
- Author:
Zhihui ZHANG
;
Jun CHENG
;
Zhiyuan SONG
- Publication Type:Journal Article
- Keywords:
canine;
sinoatrial node;
damage;
formaldehyde;
electrophysiology
- From:Journal of Third Military Medical University
2003;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility and reliability to build a sinoatrial node damage model in canine induced by formaldehyde wet dressing.Methods Twenty dogs were randomly divided into 4 groups(5 in each group) by means of random number table:2-hour,24-hour,1-week and 4-week groups after wet dressing.The sinoatrial node area of canine was damaged by wet dressing with 20% formaldehyde.Sinus node function was measured before,2 h after wet dressing and corresponding times of each group.Electrocardiogram(ECG) of body surface were recorded synchronically.Results Average wet dressing time was 6.2?2.6(3 to 12)min.Five dogs showed significantly decrease of heart rate(HR)(140?11 vs 89?6 beat/min,P
