Downregulation of P2X_7 receptor expression in neonatal rats after hypoxic-ischemic brain damage
- VernacularTitle:P2X_7受体在新生大鼠缺氧缺血性脑损伤后表达下调
- Author:
Liyan WANG
;
Wenqin CAI
;
Penghui CHEN
- Publication Type:Journal Article
- Keywords:
P2X_7 receptor;
hypoxia-ischemia;
brain damage;
rats
- From:Journal of Third Military Medical University
2003;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of P2X7 receptor expression in neonatal rats after hypoxic-ischemic brain damage(HIBD).Methods Twenty SD rats were randomized into 2 groups,control group and hypoxic-ischemic(HI) group.Western blotting and immunohistochemistry was used to detect the protein expression of P2X7 receptor in cerebal cortex,subcortical white matter and hippocampus before and after hypoxia-ischemia.Results In comparison to the sham operation controls,a significant down-regulation of the P2X7 receptor protein was observed in ischemic cerebral cortex,subcortical white matter(P
