Effects of enriched environment and impoverished environment on brain function of premature rats after hypoxic-ischemic brain damage
- VernacularTitle:丰富与贫瘠环境对新生鼠脑损伤后脑功能的影响
- Author:
Liqun LU
;
Jun JIANG
;
Xin YANG
;
Songmei LIU
- Publication Type:Journal Article
- Keywords:
hypoxic-ischemia;
environment;
glial fibrillary acidic protein;
brain function;
premature
- From:Journal of Third Military Medical University
2003;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of enriched environment and impoverished environment on brain function after hypoxic-ischemic brain damage(HIBD).Methods Three-day-old SD rats,which were divided into enriched environment group(EE),standard environment group(SE) and impoverished environment group(IE) by random digits table were used to establish HIBD model.The sham-operation rats served as control group.Different environment stimulations were administrated to the rats respectively since the 2nd day after HIBD.On the 32nd day,hanging test and incline plane test were carried out to evaluate the sensorimotor function.Morris water maze was used to evaluate the learning and memory ability.The expression of GFAP in the cortex and hippocampus was measured by the method of immunohistochemistry.Results The brain function of IE group was much worse than that of SE group(P0.05).Immunohistochemical analysis showed the expression of GFAP in the cortex and hippocampus of Sham group was significantly lower than that of other groups(P
