Losartan inhibits renal sympathetic nerve activity in Paraventricular nucleus in chronic heart failure rat
- VernacularTitle:氯沙坦通过室旁核抑制慢性心衰大鼠肾交感神经兴奋性
- Author:
Le GUI
;
Jianhua ZHU
;
Qinghui CHEN
- Publication Type:Journal Article
- Keywords:
heart failure;
paraventricular nucleus;
losartan;
renal sympathetic nerve activity
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:Left coronary artery ligation(LAD)was used to induce heart failure.Losartan was microinjected into paraventricular nucleus(PVN),heart rate(HR),blood pressure(BP)and renal sympathetic nerve activity(RSNA)were measured.The mechanism of PVN in chronic heart failure was investigated.METHODS:Sprague-Dawley male rats were selected for LAD ligation for heart failure models,the variation of cardiac function was detected by echocardiography.Losartan was microinjected into PVN,the responses of HR,BP and RSNA were analyzed.RESULTS:Compared with sham group,the level of LV was increased(P
