The clinical observation of topical olopatadine hydrochloride and FK506 for severe vernal keratoconjunctivitis in children
- VernacularTitle:奥洛他定联合FK506滴眼液治疗儿童严重春季角结膜炎的疗效观察
- Author:
Puning ZHAO
;
Zhicong WANG
;
Lin LIN
;
Chengtian YE
- Publication Type:Journal Article
- Keywords:
vernal keratoconjunctivitis;
olopatadine;
FK506
- From:
Ophthalmology in China
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of eye drops of 0.1%olopatadine hydrochloride(patanol) and 0.05%FKS06 (tacrolimus) for treating severe vernal keratoconjunctivitis in children.Design Prospective case siries.Participants 62 cases(104 eyes) of severe vernal keratoconjunctivitis aged 3-14 years old.Methods We observed the symptoms and signs of severe vernal keratoconjunctivitis before and after the treatment of 0.1%olopatadine hydrochloride and 0.05%FKS06.We examined regularly the blood,liver and kidney functions for all patients during treatment.Main Outcome Measures Symptoms and signs.Results Following by 3- 34months,all patients were much better in different degree at 1 week than that before.The papillae were decreased and almost disappeared gradually at 1 month.The corneal lesions were cured rapidly in less than 2 weeks.2 cases(3.2%) complained a little disconfort just at the beginning.38 cases(61.3%) recurred from 2 weeks to 8 months after stopping the eye drops,and were controlled rapidly after reusing the eye drops.The blood routine and the biochemical functions of all patients were normal during treatment.Conclusions 0.1% olopatadine hydrochloride and 0.05%FKS06 have remarkable effects for alleviating symptoms and signs of severe vernal keratoconjunctivitis. The patients are comfortable and content with the treatment,and side effects are very few.
