The analgesic action of oxysophoridine and its effect on the expression of PKC? in central nervous system of mice
- VernacularTitle:氧化槐定碱镇痛作用及其对小鼠中枢PKC?表达的影响
- Author:
Jinxian GAO
;
Lijun TAO
;
Jianqiang YU
;
Shaoju JIN
;
Guang YANG
;
Yonghui XU
;
Yuanxu JIANG
- Publication Type:Journal Article
- Keywords:
oxysophoridine;
analgesia;
PKC?;
dorsal horn of spinal cord;
cerebral cortex;
thalamus
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the analgesic action of oxysophoridine and its effect on the expression of protein kinase C?(PKC?) in dorsal horn of spinal cord(it should be expressed as in dorsal horn of the spinal),cerebral cortex and thalamus of the mice.Methods Hot plate test was used to observe and analyze the analgesic strength and action position of OSR through iv and icv approaches,immunohistochemistry(SABC) was taken to inspect the expression of PKC? in dorsal horn of spinal cord(it should be expressed as in dorsal horn of the spinal),cerebral cortex and thalamus of the mice after administrating OSR.Results The foot-licking latencies of mice were prolonged both iv OSR(500、250、125 mg?kg-1)and icv OSR(100,50,25 mg?kg-1)in the hot plate test(P
