The influence of polyI:C on blood capillary in mouse prostate carcinoma
- VernacularTitle:聚肌胞对小鼠前列腺癌内微血管的影响
- Author:
Yuantong TIAN
;
Zhaoyi ZENG
;
Weiwei CHEN
;
Wei HE
;
Lijuan ZHAO
- Publication Type:Journal Article
- Keywords:
polyI:C;
mouse;
prostate carcinoma;
VEGF;
eNOS;
NO;
AQP1
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of polyI:C on angiogenesis in mouse prostate carcinoma and its mechanisms.Methods Prostate carcinoma bearing mice were randomly divided into two groups according to tumor volume:contrl group and polyI:C group.After seven times′treatment,the mice were sacrificed.The content of NO in tumor was measured by nitric oxide assay kit.Tumor tissues were partly performed hematoxylin-eosin staining to observe morphological changes and distribution of vasa.Immunohisto chemical staining was used to observe the expression of VEGF,eNOS and AQP1.Results The content of NO in polyI:C group and the control was(1.22?0.77)?mol and(8.73?5.34)?mol respectively,and there was significant difference between two groups(P
