Regulation of SREBPs and its research progress in the development of nonalcoholic fatty liver
- VernacularTitle:SREBPs的调节及在非酒精性脂肪肝形成机制中的研究进展
- Author:
Rao DU
;
Meilin XIE
- Publication Type:Journal Article
- Keywords:
sterol regulatory element-binding proteins;
nonalcoholic fatty liver;
cholesterol;
triglyceride;
fatty acid;
insulin resistance
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver(NAFL)is characterized by the hepatocyte steatosis and lipid accumulation,and is a clinical syndrome of unrelated to excessive alcohol consumption. At present,patients with the syndrome obviously increase in the whole world. Sterol regulatory element-binding proteins (SREBPs) are the key transcription factors of controlling the biosynthesis of cholesterol,fatty acids and triglycerides,and adipocyte differentiation. In this paper,the regulation of SREBPs and its research progress in the development of NAFL were reviewed.
