Glyoxalase I-structure,function and role in Alzheimer′s disease
- VernacularTitle:乙二醛酶Ⅰ的结构、功能及其与阿尔采末病的关系
- Author:
Shijun YAN
;
Zhi LI
;
Wensheng ZHANG
- Publication Type:Journal Article
- Keywords:
glyoxalase I;
Alzheimer′s disease;
methylglyoxal;
AGEs;
?-oxoaldehydes;
regulatory net
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Glyoxalase system,a most effective defence system is present in cytosol of cells to scavenge ?-oxoaldehydes,which are reactive intermediates of AGEs formation.Glyoxalase Ⅰ is the key enzyme of this system.?-oxoaldehydes and AGEs are involved in the development of Alzheimer′s disease (AD). Therefore,the expression level and activity of glyoxalase I are essential to pathogenesis of AD.
