Simvastatin inhabits the adhesion and expression of chemokine fractalkine in human umbilical vascular endothelial cells induced by interleukine-18
- VernacularTitle:辛伐他汀抑制白细胞介素-18诱导的人脐静脉内皮细胞Fractalkine表达和黏附作用
- Author:
Yilun TIAN
;
Deqian JIANG
;
Xiaolan CUI
;
Fulong LIAO
- Publication Type:Journal Article
- Keywords:
simvastatin;
chemokine;
Fractalkine;
human umbilical vascular endothelial cell;
monocyte THP-1;
adhesion;
interleukine-18;
atherosclerosis
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of simvastatin on the FKN expression in human umbilical vascular endothelial cells(HUVEC)up-regulated by interleukine-18(IL-18),and the effect on adhesion of FKN to monocyte THP-1.Methods FKN expression in HUVEC was determined by reverse transcription-polymerase chain reaction (RT-PCR), and the adhesion was checked by in vitro Flow chamber.Results Incubation of HUVECs with IL-18 upregulated FKN mRNA expression(P
