The effect of resveratrol combined with arabinosylcytosin in K562 cell Fas/FasL and survivin expression
- VernacularTitle:白藜芦醇联合阿糖胞苷对人自血病K562细胞Fas/FasL、survivin表达影响
- Author:
Jianbin CHEN
- Publication Type:Journal Article
- Keywords:
Resveratrol;
Arabinosylcytosin;
K562;
Fas/FasL;
Survivin
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study was aimed to explore the apoptotic effect the K562 cells treated by resveratrol and/or arabinosylcytosin.Methods:Fas/FasL expressian was detected by immunohistochemical method and survivin expression was detected by RT-PCR in K562 cells,48 hours after treatment by resveratrol and arabinosylcytosin respectively.Results: Fas/FasL expression in K562 cells,treated by resveratrol and arabinosylcytosin respectively,was significantly increased compared with the control group(P0.05),contrary to FasL expression(P0.05).Conclusions:In conclusion the resveratrol and/or arabinosylcytosin could upregulate Fas/FasL expression and activate the apoptosis pathway of Fas/FasL to induce the apoptosis of K562 cells.It could downregulate the expression of survivin to promote apoptosis.The two drugs had synergistic effect.
