Studies on the Analgesic Effect of Polysaccharopeptide and Its Mechanism
- VernacularTitle:白介素-2参与云芝糖肽镇痛作用的研究
- Author:
Yuanrong LIU
;
Zhenlun GU
;
Qizhang YIN
- Publication Type:Journal Article
- Keywords:
polysaccharopeptide;
analgesia;
interleukin-2(IL-2);
IL-2 receptor;
mediobasal hypothalamus(MBH)
- From:
Journal of Zhejiang Chinese Medical University
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]The study focus on the analgesic effect of polysaccharopeptide(PSP)and discuss the mechanism of this analgesia. [Methods]A total of 80 rats were divided randomly into high dose of psp,medium dose of psp,low doses of psp,positive control group,negative control group.After intragastric(ig) administration of different(high,medium and low)doses of PSP for 6 days,The tail stimulation-vocalization test was used to observe the analgesic effect of PSP.The IL-2 and IL-2R expression in mediobasal hypothalamus(MBH) was studied immunohistochemically.[Results]After intragastric(ig) administration of PSP for 6 days,the pain threshold was increased significantly and a dose-effect relationship was observed.After PSP administration the IL-2 expression in MBH was increased,while the IL-2R expression in MBH was decreased.[Conclusion]PSP has a definite analgesic effect and its analgesic site is in the MBH.The analgesia might be produced by the binding with the IL-2R in MBH by IL-2 secreted by T cells after PSP was injected into the brain.
