Effect of Lianggesan on inflammation in acute lung injury rat induced by endotoxin
- VernacularTitle:凉膈散对内毒素致大鼠急性肺损伤炎症调控的影响
- Author:
Linzhong YU
;
Kongyou HU
- Publication Type:Journal Article
- Keywords:
Inflammatory mediator;
Anti-inflammatory mediator;
Acute lung injury;
Endotoxin;
Lianggesan
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To search the effects and possible mechanisms of Lianggesan on the acute lung injury(ALI) rat induced by endotoxin. Methods: Endotoxemia was induced by intravenous lipopolysaccharide (LPS,5 mg/kg), then treated with Lianggesan. The levels of TNF-?, IL-1?and IL-10 in serum and wet-to-dry weight ratio of lung were detected. Results:In LPS group the levels of TNF-? began to increase at 1h, which reached the peaks at 2h(P
