Influence of Yishen Huayu Formula on expression of connective tissue growth factor in rat with renal interstitial fibrosis
- VernacularTitle:益肾化瘀方对肾间质纤维化大鼠肾组织中CTGF蛋白表达的影响
- Author:
Linqi ZHANG
;
Zhiqing GAO
;
Weiming LI
- Publication Type:Journal Article
- Keywords:
Yishen Huayu Formula;
Rat;
Renal interstitial fi brosis;
Connective tissue growth factor
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the protective influence and mechanism of Yishen Huayu Formula on the expression of connective tissue growth factor (CTGF)in the rat with renal interstitial fibrosis. Methods: 150 rats were randomly divided into sham-opration group, model group, Lotensin treatment group, Yishen Huayu high low dose treatment groups. The rat models with renal interstitial fibrosis were induced by unilateral ureteral obstruction. The expressions of CTGF in the kidneys were observed on 3rd, 7th, 14th, 21st, 28th day. The alterations of renal the expressions of CTGF in the kidneys were observed with the ?-actin as intrinsic control. Results: Compared with the control group,the expression of CTGF increased signifi cantly in model group(P
