Effects of Erbie Decoction on the hepatocyte apoptosis-related factors Fas/Fas-L in rat with liver fibrosis
- VernacularTitle:二鳖汤对肝纤维化大鼠肝细胞凋亡相关因子Fas/Fas-L的影响
- Author:
Suyang ZHANG
;
Rongheng LI
;
Shumei WANG
;
Shengchi XIONG
- Publication Type:Journal Article
- Keywords:
Erbie Decoction;
Liver fi brosis;
Apoptosis;
TGF-?1;
Fas/Fas-L
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate effects of Erbie Decoction on the hepatocyte apoptosis-related factors Fas/Fas-L in rat with liver fi brosis,and to explore its anti-fi brosis mechanism. Methods: To Induce immune Liver fibrosis of rat model were established by intraperitoneal injection of pig serum. 48 rats were randomly divided into normal group, model group, pretreatment groups(high, middle and low dose groups of Erbie Decoction, and Fufang Biejia Ruangan Pills group. One week after the feeding adaptation, in addition to the normal group, other groups were given intraperitoneal injection of pig serum, each rat with 0.5ml, twice a week. At the same time, pretreatment groups were given intragastric administration daily. After 9 weeks, the expression of TGF-?1 and Fas/Fas-L were detected with immunohistochemistry assay. Results: Compared with normal group, in model group, TGF-?1 and Fas/Fas-L increased obviously(P
