Detection of hepatitis B virus pre-C region mutation in cases of chronic hepatitis B and its relationship with IFN treatment
- VernacularTitle:慢性乙型肝炎HBV DNA前C区变异检测及其与干扰素治疗关系的研究
- Author:
Guojun SUN
;
Wei CUI
;
Zhiwei LI
- Publication Type:Journal Article
- Keywords:
HBV DNA;
mutation;
IFN-alpha
- From:
Chinese Journal of Practical Internal Medicine
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between hepatitis B virus pre-core region 1896 site mutation in cases of chronic hepatitis B and IFN-alpha treatment.Methods 200 patients with chronic hepatitis B were randomly divided into experimental group(n=100) and control group(n=100).The patients in experimental group were treated with regular liver-protective drugs and IFN-alpha,while Control group patients received only regular liver-protective drugs for 6 months.PCR-RFLP were used to detect hepatitis B virus(HBV)DNA with pre-C region 1896 site mutation in two grops pre and post treatment.Results The mutation rates before interferon treatment were 20%(20/100) and 18%(18/100) in experimental group and control group,respectly.After treatment,the effective rates in experimental group were 60%(12/20) and 50%(40/80) in Patients with Chronic Hepatitis B variant and wild strain virus Infection,respectly.The effective rate in experimental group was significantly higher than that in control group.Conclusion IFN-alpha therapy was not correlated with genomic variability of the core region.
