Tumor chemosensitization strategies based on apoptosis manipulations
- VernacularTitle:基于调控细胞凋亡的肿瘤化疗增敏策略
- Author:
Xiaodong LIU
;
Hua SUN
;
Gengtao LIU
- Publication Type:Journal Article
- Keywords:
multidrug-resistance(MDR);
chemotherapy;
apoptosis;
anti-apoptotic factor;
pro-apoptotic factor;
5-bromotetrandrine
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
MDR(multidrug-resistance)is a major obstacle in the chemotherapy of cancer.Numerous mechanisms are known to contribute to MDR,alterations at the level of apoptosis control are one of those mechanisms except overexpression of drug efflux pumps.This review focuses on the research progression of alterations at the level of apoptosis inducing MDR,and some of the strategies that have been used in an attempt to chemosensitize resistant tumors by manipulating dysregulated apoptosis pathways.
