Expression and role of peroxisome proliferator-activated receptor ? and nuclear factor-?B in pulmonary fibrosis
- VernacularTitle:PPAR?和NF-?B在肺纤维化中的表达与意义
- Author:
Qing LIN
;
Lianfang NI
;
Yali REN
;
Xinmin LIU
- Publication Type:Journal Article
- Keywords:
Pulmonary fibrosis;
PPAR gamma;
NF-kappa B
- From:
Journal of Peking University(Health Sciences)
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the expression of peroxisome proliferator-activated receptor ?(PPAR?) and nuclear factor-?B(NF-?B) in lungs in patients with pulmonary fibrosis,and to explore their effect on the pathogenesis of pulmonary fibrosis.Methods: Immunohistochemical technology was performed to investigate the PPAR? and NF-?B expression in lung specimens from 16 cases of pulmonary fibrosis and 10 cases of normal controls.Results: The positive score of PPAR?(0.35?0.08) in fibrosis group was lower than that in control group(0.42?0.04,P
