EFFECT OF CHLOROGENIC ACID ON GLUCOSE CONSUMPTION IN HepG2 CELLS PRETREATED WITH HIGH INSULIN AND HIGH OLEIC ACID
- VernacularTitle:氯原酸对高胰岛素与高油酸状态下HepG2细胞葡萄糖利用的影响
- Author:
Zhizhuo HUANG
;
Yanbo CHEN
;
Cuiqing CHANG
- Publication Type:Journal Article
- Keywords:
chlorogenic acid;
HepG2 cell;
insulin resistance;
hepatic steatosis;
glucose consumption
- From:
Acta Nutrimenta Sinica
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the modulation of chlorogenic acid (CGA) on glucose metabolism in HepG2 cells pretreated with high insulin and high oleic acid (OA). Methods Cultured HepG2 cells induced by high insulin and oleic acid for insulin resistance and steatosis respectively, were co-cultured with different concentrations of CGA (10,20,40,80 mg/L) for 24h. The morphological changes were observed and glucose consumptions of cells were measured by glucose oxidase method. Results Compared to control group, CGA could significantly increase glucose consumption of normal HepG2 cells and the dosedependent effect was noted between 10-40 mg/L(P
