Regulation of N-Acetyl-D-glucosamine on macrophages function of stressed mice
- VernacularTitle:N-乙酰氨基葡萄糖对应激小鼠巨噬细胞吞噬功能的调节作用
- Author:
Yijin PEI
;
Xiaolan WU
;
Fangyuan MAO
;
Wanyan CHEN
;
Junkang LIU
- Publication Type:Journal Article
- Keywords:
stress;
N-Acetyl-D-glucosamine;
macrophages;
phagocytosis;
immune
- From:Journal of Third Military Medical University
2003;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the regulative role of N-Acetyl-D-glucosamine(GlcNAc) on the stressed mice macrophages function.Methods The stressed mice model was established by electric footshock method.The mice were divided into 5 groups:normal control group,stressed mice model group,low dose Glc-NAc treatment group(0.25 ml 15% GlcNAc),medium-dose GlcNAc treatment group(0.5 ml 15% GlcNAc) and high-dose GlcNAc treatment group(1 ml 15% GlcNAc).GlcNAc was intragastrically injected to corresponding mice 2 h before the electrical stimulation.Peritoneal macrophage(PM?) phagocytosis capability was detected by phagocytosis saccharomycete assay,and PM? energy metabolism was detected by MTT assay.Results Compared with normal control group,stressed mice PM? phagocytosis capability was significantly lower(P
