Clinical significance of expressions of vascular endothelial growth factor and matrix metalloproteinase-9 in prostate carcinoma
- VernacularTitle:血管内皮生长因子和基质金属蛋白酶-9在前列腺癌中的表达及其相互关系
- Author:
Qinwen WANG
;
Xinwei DIAO
;
Zhengtang CHEN
;
Mingfu YE
;
Jianping XU
;
Yali WANG
- Publication Type:Journal Article
- Keywords:
prostate cancer;
immunohistochemical staining;
vascular endothelial growth factor;
matrix metalloproteinase-9
- From:Journal of Third Military Medical University
2003;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expressions of vascular endothelial growth factor(VEGF) and matrix metalloproteinase-9(MMP-9) in prostate cancer.Methods The expression of VEGF and MMP-9 in 148 samples of pathologically verified human prostate cancer(PCa) and 10 samples of benign prostatic hyperplasia(BPH) were detected by immunohistochemical staining.Results VEGF was overexpressed in 98 of 148 tumor tissues(66.2%) and MMP-9 was overexpressed in 58 of 148 tumor tissues(39.2%).Both of them were significantly higher than those in BPH(P0.05).But the expression of VEGF was correlated with that of MMP-9.Conclusion The expressions of VEGF and MMP-9 are closely associated with the development of prostate cancer.Therefore VEGF and MMP-9 may be clinically useful as predictor of patients'survival.
