Study on effect and mechanism of Anchang Yuyang Decoction with Jiawei Shengji Powder on ulcerative colitis in rats
- VernacularTitle:安肠愈疡汤口服合加味生肌散灌肠对实验性溃疡性结肠炎大鼠的影响
- Author:
Lili CHI
;
Xia DAI
- Publication Type:Journal Article
- Keywords:
Ulcerative Colitis;
Anchang Yuyang Decoction with Jiawei Shengji Powder;
Experimental study
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study effect and mechanism of Anchang Yuyang Decoction with Jiawei Shengji Powder (ACYYD&JWSJP) on ulcerative colitis (UC) in rats. Methods: Ninety SD rats were divided randomly into six groups: normal control group,pathologic model control group,ACYYD group, JWSJP group, ACYYD & JWSJP group And Solfasalazine (SASP) treatment group. The model of ulcerative colitis were established by given 2,4,6-TNBS. After medication for 3 weeks, the parameters including colonic gross morphology, colon tissue injury scores, MPO activity, the content of IL-1?, IL-8, TNF-? and IL-10 were observed. Results: Inflammation relieving of colonic mucosa and ulcer healing were found in all treatment group rats at different degree. Colonic gross morphology, colon tissue injury scores,MPO activity and the level of IL-1?,IL-8, TNF-? decreased, while levels of IL-10 increased after therapy (P
