Effect of glucocorticoid on the contents of IL-5,IL-12,IL-18 in allergic rhinitis rats
- VernacularTitle:糖皮质激素对变应性鼻炎大鼠血清IL-5、IL-12、IL-18含量变化的影响
- Author:
Zhiqiang YAN
;
Shenghong GAO
;
Jun ZHANG
;
Xiaoli SHAO
- Publication Type:Journal Article
- Keywords:
glucocorticoids;
rhinitis,allergic;
interleukins
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish allergic rhinitis(AR) model in rats to observe the changes in IL-5,IL-12 and IL-18 in serum of AR rats,and explore the influence of glucocorticoid on IL-5,IL-12 and IL-18 expression,and to elucidate further the pathogenesis of AR and the mechanism of glucocorticoid.Methods Thirty-six rats were divided into three groups:normal control(NC) group,AR group and dexamethasone intervention(Dex) group(12 each).Animals in AR and Dex group were sensitized with egg albumin,and in NC group were treated with normal saline as control.After sensitization and reproduction of AR model,rats in AR group received no treatment,while those in Dex group were treated with dexamethasone(5mg/kg,once a day) for 5 days.The changes in behavior was examined,and pathology of nasal mucosa were observed with HE staining,and the expressions of IL-5,IL-12 and IL-18 in serum were determined with ELISA.Results Compared with NC group,the frequency of sneesing and nose-scratching,and the expressions of IL-5 and IL-18 were increased obviously(P
