Drug administration in the patients with chronic renal failure
- VernacularTitle:慢性肾功能不全的药物治疗
- Author:
Nan CHEN
- Publication Type:Journal Article
- Keywords:
chronic renal failure;
blood purification;
pharmacokinetics
- From:
Chinese Journal of Practical Internal Medicine
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
When the patients with chronic renal failure need drug therapy,we must select the appropriate drugs and adjust the drug delivery methods and dosage according to the renal function of these patients,at the same time we have to consider the factors such as age,sex,weight,combined medication,damage of other organs and so on,the therapeutic drug concentration monitoring should be paid attention to.For patients with blood purification,if the drug mainly removed by the kidneys,adjustments of drug administration must be based on the molecular weight of drug,volume of distribution,protein binding rate,mode of dialysis and hemodialyzer.We must ensure the drug efficacy and reduce the adverse reactions of drugs at the same time in the patients of renal insufficiency.
