Evaluation of insulin sensitizer based on non-insulin-dependent diabetes mellitus Zucker fa/fa rat model
- VernacularTitle:以自发性大鼠模型评价胰岛素增敏剂药效时的初步探讨
- Author:
Xiaolin WANG
;
Zongyin QIU
;
Yongpeng XIA
- Publication Type:Journal Article
- Keywords:
Zucker fa/fa rat;
rosiglitazone;
hyperinsulinemic-euglycemic clamps;
insulin sensitivity
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate some points in evaluating the effects of insulin sensitizer on obesityassociated non-insulin-dependent diabetes mellitus Zucker fa/fa rat model. Methods Total 20 male Zucker fa/fa rats were divided into model group and rosiglitazone groups. Another 10 male Zucker fa/? rats served as normal control. Rosiglitazone at 6 mg/kg was given intragastrically once per day for 4 weeks,and the rats of the other 2 groups were fed with same solvent at same volume. Results Rosiglitazone reduced the levels of fasting insulin,triglyceride ( TG) and free fatty acid ( FFA) of Zucker fa/fa rats ( P
