Effects of Qingrehuayuziyin Fang on lymphocyte apoptosis and expression of Fas and FasL in peripheral blood in the patients with systemic lupus erythematosus
- VernacularTitle:清热化瘀滋阴方对系统性红斑狼疮外周血淋巴细胞凋亡及Fas、FasL基因表达的影响
- Author:
Wei LIANG
;
Lin JIN
;
Ling GONG
;
Liling ZHANG
;
Hui LIAO
;
Ying CAI
- Publication Type:Journal Article
- Keywords:
Qingrehuayuziyin Fang;
systemic lupus erythematosus;
apoptosis;
Fas;
FasL
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of Qingrehuayuziyin Fang on lymphocyte apoptosis and expression of Fas and FasL in peripheral blood in the patients with systemic lupus erythematosus(SLE).METHODS: Eighty patients with SLE were selected and divided randomly into two groups,40 in the therapy group and 40 in control group respectively.Patients were get the treatment of Qingrehuayuziyin Fang combined hormone(prednisone) as therapy group and get hormone treating only as control group.After treating three months,lymphocyte were collected to be detected the rate of apoptosis by flow cytometer.Meanwhile,the expression of Fas and FasL were analyzed by RT-PCR.RESULTS: After three months treating,the rate of lymphocyte apoptosis was decreased significantly in therapy group compared with that in control group(P
