Study between related factors of hepatocellular carcinoma and ubiquitin proteasome pathway
- VernacularTitle:肝细胞癌相关因子与泛素-蛋白酶体通路关系的研究
- Author:
Shuai WANG
;
Liang CHU
;
Xiaowei HU
;
Jihong YAO
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
ubiquitin-proteasome pathway(UPP);
HBV;
P27;
NF-?B
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma is one of the largest causes of cancer-related deaths worldwide for which there are very limited effective treatment options.The ubiquitin-proteasome pathway(UPP) has rapidly become acknowledged as both critical mechanism for cellular biological function and a latent target of regulation of cancer-related disease.This review focus on the role of ubiquitin-proteasome pathway in hepatocellular carcinoma and its correlation factors(HBV、P27、NF-?B,et al),in order to find novel therapeutic interventions against the genesis and development of hepatocellular carcinoma.
