Effect and mechanism of astragalus polysaccharides on apoptosis of the islet beta cell in diabetes mellitus rats
- VernacularTitle:黄芪多糖对糖尿病大鼠胰岛?细胞凋亡作用及机制的研究
- Author:
Shumei MAO
;
Chengde LI
;
Lin WANG
;
Jinhong WANG
;
Gong DAI
;
Bai KANG
- Publication Type:Journal Article
- Keywords:
astragalus polysaccharides;
STZ;
DM;
TNF-?;
Caspase-3,apoptosis;
pancreatic beta cells
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To probe the mechanism of the therapeutic effect of APS against DM rats by measuring the level of TNF-?,as well as observing the change of caspase-3 protein in pancreatic beta cells.Methods Thirty DM rats induced by STZ were randomly divided into three groups:DM group,APS low dosage group,APS high dosage group,and another 10 normal rats were taken as the control group.The drug was given for 6 weeks.The research included measuring the level of TNF-? in serum and the expression of caspase-3 protein in pancreatic beta cells.Results ① The level of TNF-? was higher in model group than that of the normal group(P
