Inhibitory effect of anticomplementary protein atrase B from cobra venom on platelet aggregation induced by activated complement
- VernacularTitle:蛇毒抗补体蛋白atrase B抑制补体活化引起的血小板聚集
- Author:
Caie WANG
;
Qianyun SUN
;
Min LI
;
Jingshan SHI
- Publication Type:Journal Article
- Keywords:
anticomplementary protein;
complement activation;
platelet activation;
platelet aggregation;
cobra venom factor;
cobra venom;
P-selectin;
GPⅡb/Ⅲa
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the inhibitory effect of atrase B on human platelet aggregation induced by activated complement.Methods By employing CVF to activate complement,the effect of atrase B on gel filtered platelet aggregation induced by activated complement was measured by turbidimetry and the expression of P-selectin and GPⅡb/Ⅲa on platelet membrane were detected by flow cytometry.Results Atrase B inhibited platelet aggregation and the expression of P-selectin and GPⅡb/Ⅲa on platelet membrane induced by activated complement.Conclusion Anticomplementary protein atrase B from Naja atra venom can significantly inhibit platelet activation and aggregation induced by activated complement.
