Controlling pathologic pain through modulating the cAMP signal pathway
- VernacularTitle:调控环磷腺苷信号通路治疗病理性疼痛
- Author:
Jian LIU
;
Buwei YU
- Publication Type:Journal Article
- Keywords:
cAMP;
pathologic pain;
inflammatory response;
phosphodiesterase;
inflammatory cells;
glia
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Pathologic pain is a common suffering and does great harm to people health. Therefore it is important to search some suitable targets for pain management. Recently it has been shown that activated inflammatory cells and glia are strongly implicated in the pathologic pain. Cyclic 3',5'-adenosine monophosphate,a universal intracellular second messenger,has been proven to inhibit the activity of inflammatory cells and glia by enhancing its activity,further to control pathologic pain. This review presents the current understanding of the underlying mechanisms for the inhibitive effect of cAMP signal pathway in inflammatory cells and glia,and the effect of phosphodiesterase inhibitors used for relieving pathologic pain.
