Protective effect of oleoylethanolamide on focal cerebral ischemia in mice
- VernacularTitle:油酰乙醇胺对小鼠局灶性脑缺血的保护作用
- Author:
Lichao YANG
;
Wushuang YANG
;
Yu ZHOU
;
Xin JIN
- Publication Type:Journal Article
- Keywords:
oleoylethanolamide;
middle cerebral artery occlusion;
cerebral ischemia;
reperfusion injury;
effective doses;
optimal therapeutic time point;
mice
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of oleoylethanolamide (OEA),a new PPAR? agonist,on focal cerebral ischemia in mice.Methods Transient focal cerebral ischemia in mice was induced by middle cerebral artery occlusion for 1.5 h. OEA was orally administered either with multiple doses (10,20,40 mg?kg-1) once a day for 3 days before ischemia or single dose (40 mg?kg-1) at 0.5 h before or 1 h before ischemic,the same time of reperfusion or 1 h after reperfusion respectively.Neurological deficit score,infarct volume and brain edema were determined.Results Pretreatment with multiple doses (20,40 mg?kg-1) of OEA before ischemia or single dose (40 mg?kg-1) of OEA at 0.5 h before ischemia or at the same time of reperfusion significantly attenuated neurological deficit score,decreased infarct volume and alleviated brain edema,and the treatment at the time of reperfusion had the most marked effect.Conclusion Oleoylethano-lamide has a dose-and time-dependent neuroprotective effect on the injury in the acute phase of transient focal cerebral ischemia in mice,with effective doses of 20 mg?kg-1 and 40 mg?kg-1 and the optimal therapeutic time point of the same time of reperfusion.
