Genetic polymorphisms of cytochrome P450 oxidoreductase and its effect on drug metabolism
- VernacularTitle:CYP450氧化还原酶的遗传多态对药物代谢的影响
- Author:
Lan FAN
;
Xiangdong PENG
;
Zhihua GUO
;
Honghao ZHOU
- Publication Type:Journal Article
- Keywords:
cytochrome P450 oxidoreductase;
cytochrome P450 monooxygenases;
drug metabolism;
polymorphism;
pharmacogenetics;
eletron donor
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Cytochrome P450 oxidoreductase (POR) is the only electron donor for all microsome Cytochrome P450 monooxygenases which are phase I metabolizing enzymes responsible for the metabolism of more than 80% drugs used in clinic.Also,POR metabolizes some anti-tumor prodrugs directly.Therefore,the alteration in POR activity caused by the polymorphisms of POR gene will be of great clinical significance.This review summarizes the newest advancement on the effects of POR polymorphisms on drug metabolism.
