DJ-1 gene:a new potential target of drugs for Parkinson's disease
- VernacularTitle:DJ-1基因:抗帕金森病药物作用的可能新靶点
- Author:
Hongning ZHANG
;
Chunna AN
;
Xiaoping PU
- Publication Type:Journal Article
- Keywords:
DJ-1;
Parkinson's disease;
target;
oxidafive stress;
chaperone;
thanscription regulation
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is a neurodegenerative disease commonly found in middle-aged and elderly people,and its onset is attributable to both genetic and environmental factors. The gene mutation and oxidative damage of DJ-1 correlate with familial and sporadic PD,respectively. The mechanisms by which DJ-1 gene mutation and oxidative damage lead to PD include oxidative stress,mitochondrial dysfunction and proteasome dysfunction.Furthermore,DJ-1 is a biomarker of sporadic PD and it may become a new potential target of anti-PD drugs.
